von Mutius Lab
Research topics
- Determinants of childhood asthma and allergies
Erika von Mutius, MD MSc
✉ Erika.Von.Mutius@med.lmu.de
☎ +49-89-4400-57897
We are an interdisciplinary research group interested in discovering the causes of childhood asthma and allergies. Our group comprises researchers from epidemiology, statistics, immunology and clinical medicine. Over the last decades we have been involved in a number of large multicenter interdisciplinary research projects, mainly focusing on the role of genetic, environmental and microbial determinants for childhood asthma and allergies. Asthma is one of the major epidemic illnesses in children with an estimated total burden in the 25 EU member states of €3.0 billion each year.
Mira Berbig, Study Coordinator, mira.berbig@med.uni-muenchen.de
Tabea Brick, Research Assistant tabea.brick@med.uni-muenchen.de
Sibylle Contento, Study Physician, sibylle.contento@med.uni-muenchen.de
Stefanie Hollunder, Study Physician, stefanie.hollunder@med.uni-muenchen.de
Alexander Hose, Statistician, Alexander.Hose@med.uni-muenchen.de
Nicola Korherr, Study Assistant, nicola.korherr@med.uni-muenchen.de
Nicole Maison, Medical Doctor, nicole.maison@med.uni-muenchen.de
Jutta Mersch, Assistant, jutta.mersch@med.uni-muenchen.de
Edith Ries, Data Manager, edith.ries@med.uni-muenchen.de
Elisabeth Schmaußer-Hechfellner, Data Manager, Elisabeth.Schmausser-Hechfellner@med.uni-muenchen.de
Sheena Sharma, Study Physician, sheena.sharma@med.uni-muenchen.de
Louisa Späth, Assistant, louisa.spaeth@med.uni-muenchen.de
Christine Strunz-Lehner, Study Coordinator, Christine.Strunzlehner@med.uni-muenchen.de
Daniel Walter, Data Manager, daniel.walter@med.uni-muenchen.de
Esther Zeitlmann, Study Coordinator, esther.zeitlmann@med.uni-muenchen.de
10 most important publications:
1. Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med. 2016 Aug 4;375(5):411-421.
2. Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE (Protection against Allergy Study in Rural Environments) Study Group. The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21. Am J Respir Crit Care Med. 2016 Apr 15;193(8):889-97.
3. Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, Madeira FB, Beyaert R, van Loo G, Bracher F, von Mutius E, Chanez P, Lambrecht BN, Hammad H. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science. 2015 Sep 4;349(6252):1106-10.
4. Depner M, Ege MJ, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Kaulek V, Krauss-Etschmann S, Riedler J, Braun-Fahrländer C, Roduit C, Lauener R, Pfefferle PI, Weber J, von Mutius E; PASTURE Study Group. Atopic sensitization in the first year of life. J Allergy Clin Immunol. 2013 Mar;131(3):781-8.
5. Illi S, Depner M, Genuneit J, Horak E, Loss G, Strunz-Lehner C, Büchele G, Boznanski A, Danielewicz H, Cullinan P, Heederik D, Braun-Fahrländer C, von Mutius E; GABRIELA Study Group. Protection from childhood asthma and allergy in Alpine farm environments-the GABRIEL Advanced Studies. J Allergy Clin Immunol. 2012 Jun;129(6):1470-7.e6.
6. Ege MJ, Mayer M, Normand AC, Genuneit J, Cookson WO, Braun-Fahrländer C, Heederik D, Piarroux R, von Mutius E; GABRIELA Transregio 22 Study Group. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011 Feb 24;364(8):701-9.
7. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WOCM; GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010 Sep 23;363(13):1211-1221.
8. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WO. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007 Jul 26;448(7152):470-3.
9. Illi S, von Mutius E, Lau S, Niggemann B, Grüber C, Wahn U; Multicentre Allergy Study (MAS) group. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006 Aug 26;368(9537):763-70. Erratum in: Lancet. 2006 Sep 30;368(9542):1154.
10. Riedler J, Braun-Fahrländer C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E; ALEX Study Team. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001 Oct 6;358(9288):1129-33.
Complete list of publications:
von Mutius Lab
Postal Address:
LMU Klinikum, AoeR
Dr. von Haunersches Kinderspital
Professor Erika von Mutius, MD MSc
Lindwurmstrasse 4
80337 Muenchen
Visitor’s Address:
Women’s Hospital of the University of Munich
Maistrasse 11
80337 Muenchen
Email: louisa.spaeth@med.uni-muenchen.de