en
  • German - de
  • English - en
  • Clinical research
      Interdisciplinary pediatric study center (Hauner iPSC)
        Ped-COVID-19 Study
          Michael Albert
            Scivias Study
              TRACE Study
            • Research Labs
                Binder Lab
                  Braun Lab
                    Feuchtinger Lab
                      Griese Lab
                        Hauck Lab
                          Hübner Lab
                            Jeremias lab
                              Kim-Hellmuth Lab
                                Klein Lab
                                  Kotlarz Lab
                                    Lange-Sperandio Lab
                                      von Mutius Lab
                                        Schaub Lab
                                          Schwerd Lab
                                            Schmid Lab
                                              Koletzko Lab
                                            • PhD Program
                                            • Technology platforms
                                                Bioinformatics
                                                  Flow Cytometry
                                                    High throughput sequencing
                                                      Microscopy
                                                        Pre-GMP Facility
                                                          Mass spectrometry
                                                            Hauner Biobank
                                                          • News/Events
                                                              Meinhard von Pfaundler-Lectures
                                                                Klaus Betke Symposium
                                                              • Join us!
                                                              1. CCRC-HaunerEN
                                                              2. Clinical research
                                                              3. Scivias Study

                                                              Scivias Study

                                                              • Aims of the Study:


                                                                • Identification of new biomarkers for the overall assessment of the systemic health status of childrenDevelopment of a novel diagnostic tool in children 
                                                                • Establishment of a normal range for fundus photography, OCT and OCT angiography with regard to retinal changes in various age groups

                                                                • Evaluation of the value of optical fundus evaluation in (early) diagnosis of a rare disease
                                                                • Establishing a reference range for changes in the transcriptome, metabolome and proteome in various age groups and in various acute and chronic diseases
                                                                • Correlation of systems biology data with disease activities of rare diseases
                                                                • Specification of phenotyping of patients within different disease groups

                                                              • Scivias Study

                                                                Project Summary

                                                                Early detection of diseases is a central challenge for pediatric medicine. The earlier a disease is discovered, the easier it is to avoid complications and sequelae and to reduce long-term morbidity. This is particularly relevant for children with rare diseases in whom the diagnostic process is often delayed. Children with rare and chronic diseases are usually only diagnosed when their disease manifests or complications arise. Thus, there is an urgent need to develop and use new sensitive and specific diagnostic methods, preferably as non-invasive as possible.

                                                                Next generation sequencing technologies have revolutionized human genetics. A growing number of hereditary monogenic rare diseases has been identified, leading to a better understanding of molecular processes even in multifactorial diseases. In addition to genomics, other omics-technologies (e.g. transcriptomics, metabolomics, proteomics, immunomics) complement our scientific armamentarium to comprehensively assess states of diseases. A challenge of these technologies is to integrate and interpret these large datasets. Emerging data suggest that combining multi-layer omics data with digital clinical data will allow us to improve diagnostics, to optimize prevention, and to design definitive cures. Advances in machine learning enabling pattern recognition and statistical associations, offer new perspectives for developing innovative and non-invasive diagnostic methods.

                                                                In the context of this non-randomized, monocentric observation study, the benefit of using a combination of pattern recognition of image data of the retina by fundus photography and optical coherence tomography (OCT) in combination with the analysis of various OMICS data (genome, transcriptome, proteome and metabolome) will be explored in search of markers for rare and chronic childhood diseases. Retinal images and OMICS data are pseudonymized and subjected to machine learning algorithms. Starting from classical nosological entities, we will compare the data not only within defined groups but also across phenotypes, aiming to shed light on pleiotropic factors. Once associations between genomic and phenotypic data sets become apparent, new hypotheses will be developed and tested in suitable model systems. 

                                                                Multi-OMICS methods

                                                                Content will follow shortly.

                                                                A.I. analysis

                                                                Content will follow shortly.

                                                              • Inquieries only via the official e-mail adress: Scivias.Hauner@med.uni-muenchen.de

                                                                Prof. Dr. med. Dr. sci. nat.  Christoph Klein
                                                                Studienleitung/Chefarzt
                                                                Mehr zur Person
                                                                Dr. med. Katharina Danhauser
                                                                Stellvertretende Studienleitung
                                                                E-mail
                                                                Mehr zur Person
                                                                PD Dr. Claudia Priglinger 
                                                                Stellvertretend Studienleitung Augenklinik
                                                                E-mail
                                                                Dr. med. Anna-Lisa Lanz
                                                                OMICs-Labor, Laborleitung
                                                                E-mail
                                                                Larissa Mantoan
                                                                Studienärztin
                                                                E-mail
                                                                Mehr zur Person
                                                                Dr. med. Rebekka Astudillo, DTMIH
                                                                Studienärztin
                                                                E-mail
                                                                Mehr zur Person
                                                                Dr. med. Selina Gläser
                                                                Studienärztin
                                                                E-mail
                                                                Mehr zur Person
                                                                Dominik Knebel
                                                                Wissenschaftlicher Mitarbeiter Augenklinik
                                                                E-mail
                                                                Mehr zur Person
                                                                Dr. Benedikt Schworm 
                                                                Wissenschaftlicher Mitarbeiter Augenklinik
                                                                E-mail
                                                                Sachiko Kwaschnowitz; M.Sc.
                                                                Study Nurse
                                                                E-mail
                                                                Karla Strniscak
                                                                Projektmitarbeiterin, MFA
                                                                E-mail
                                                                Mehr zur Person
                                                                Monika Prothmann
                                                                OMICs-Labor, leitende TA
                                                                E-mail
                                                                Daniel Weiß
                                                                Informatiker
                                                                E-mail
                                                                Dr. Susanne Pangratz-Fuehrer
                                                                Wissenschaftliche Mitarbeiterin, Projekt Management
                                                                E-mail
                                                                Prof. Dr. med. Dr. sci. nat.  Christoph Klein
                                                                Studienleitung/Chefarzt
                                                                Mehr zur Person
                                                                Dr. med. Katharina Danhauser
                                                                Stellvertretende Studienleitung
                                                                E-mail
                                                                Mehr zur Person
                                                                PD Dr. Claudia Priglinger 
                                                                Stellvertretend Studienleitung Augenklinik
                                                                E-mail
                                                                Dr. med. Anna-Lisa Lanz
                                                                OMICs-Labor, Laborleitung
                                                                E-mail
                                                                Larissa Mantoan
                                                                Studienärztin
                                                                E-mail
                                                                Mehr zur Person
                                                                Dr. med. Rebekka Astudillo, DTMIH
                                                                Studienärztin
                                                                E-mail
                                                                Mehr zur Person
                                                                Dr. med. Selina Gläser
                                                                Studienärztin
                                                                E-mail
                                                                Mehr zur Person
                                                                Dominik Knebel
                                                                Wissenschaftlicher Mitarbeiter Augenklinik
                                                                E-mail
                                                                Mehr zur Person
                                                                Dr. Benedikt Schworm 
                                                                Wissenschaftlicher Mitarbeiter Augenklinik
                                                                E-mail
                                                                Sachiko Kwaschnowitz; M.Sc.
                                                                Study Nurse
                                                                E-mail
                                                                Karla Strniscak
                                                                Projektmitarbeiterin, MFA
                                                                E-mail
                                                                Mehr zur Person
                                                                Monika Prothmann
                                                                OMICs-Labor, leitende TA
                                                                E-mail
                                                                Daniel Weiß
                                                                Informatiker
                                                                E-mail
                                                                Dr. Susanne Pangratz-Fuehrer
                                                                Wissenschaftliche Mitarbeiterin, Projekt Management
                                                                E-mail
                                                              • Scivias Study

                                                                Dr. von Hauner Children's Hospital, University Hospital LMU Munich

                                                                Lindwurmstrasse 4
                                                                80337 Munich
                                                                E-Mail

                                                              Thank you to all donors and supporters of the Scivias study

                                                              The Scivias study is kindly supported by Carl Zeiss AG and Munich Re, among others.

                                                              Research at CCRC Hauner

                                                              Contact LMU Klinikum

                                                              Contact CCRC Hauner

                                                              Haunersches

                                                              CCRC Hauner

                                                              Kinderklinik und Kinderpoliklinik

                                                              im Dr. von Haunerschen Kinderspital

                                                              Ludwig Maximilians Universität München

                                                              Lindwurmstr. 4

                                                              80337 Munich, Germany

                                                              ☎ +49-89-4400-57705

                                                              Login for editors
                                                              Imprint | Data-Safety
                                                              en
                                                              • German - de
                                                              • English - en

                                                              Comprehensiv...

                                                              • Clinical research
                                                                • Interdisciplinary pediatric study center (Hauner iPSC)
                                                                • Ped-COVID-19 Study
                                                                • Michael Albert
                                                                • Scivias Study
                                                                • TRACE Study
                                                              • Research Labs
                                                                • Binder Lab
                                                                • Braun Lab
                                                                • Feuchtinger Lab
                                                                • Griese Lab
                                                                • Hauck Lab
                                                                • Hübner Lab
                                                                • Jeremias lab
                                                                • Kim-Hellmuth Lab
                                                                • Klein Lab
                                                                • Kotlarz Lab
                                                                • Lange-Sperandio Lab
                                                                • von Mutius Lab
                                                                • Schaub Lab
                                                                • Schwerd Lab
                                                                • Schmid Lab
                                                                • Koletzko Lab
                                                              • PhD Program
                                                              • Technology platforms
                                                                • Bioinformatics
                                                                • Flow Cytometry
                                                                • High throughput sequencing
                                                                • Microscopy
                                                                • Pre-GMP Facility
                                                                • Mass spectrometry
                                                                • Hauner Biobank
                                                              • News/Events
                                                                • Meinhard von Pfaundler-Lectures
                                                                • Klaus Betke Symposium
                                                              • Join us!