Hauck Lab

Inborn errors of immunity constitute a heterogeneous group of monogenetic model disorders that manifest with autoinflammation, immunodeficiency, autoimmunity and immunological malignancy predisposition. We aim at illuminating their molecular genetics and the molecular, cellular and systems biological pathophysiologies. We thereby increase our knowledge in human immunity and develop innovative prophylactic and therapeutic strategies for patients suffering from these rare diseases.

PD Dr.med. Dr.sci.nat. Fabian Hauck

Dr. rer. nat. Thomas Magg

Dr. med. Anna-Lisa-Lanz

Dr. med. Johannes Rädler

Msc Jitka Smetanová

Irmgard Eckerlein (MTA)

Mayumi Hofmann (MTA)

Selected publications

Mishra H, Schlack-Leigers C, Lim E L, Thieck O, Magg T, Raedler J, Wolf C, Klein C, Ewers H, Lee-Kirsch M A, Meierhofer D, Hauck F*, Majer O*. Endosome dysfunction leads to gain-of-function TLR7 and human lupus. bioRxiv: April 3, 2023. (Preprint, no IF, Original Article). *These authors contributed equally.

Speckmann C, Nennstiel U, Hönig M, Albert MH, Ghosh S, Schuetz C, Brockow I, Hörster F, Niehues T, Ehl S, Wahn V, Borte S, Lehmberg K, Baumann U, Beier R, Krüger R, Bakhtiar S, Kuehl JS, Klemann C, Kontny U, Holzer U, Meinhardt A, Morbach H, Naumann-Bartsch N, Rothoeft T, Kreins AY, Davies EG, Schneider DT, Bernuth HV, Klingebiel T, Hoffmann GF, Schulz A, Hauck F. Prospective Newborn Screening for SCID in Germany: A First Analysis by the Pediatric Immunology Working Group (API). J Clin Immunol. 2023 Feb 27:1-14. doi: 10.1007/s10875-023-01450-6. (IF 8.542, Original Article).

Lévy R, Gothe F, Momenilandi M, Magg T, Materna M, Peters P, Raedler J, Philippot Q, Rack-Hoch AL, Langlais D, Bourgey M, Lanz AL, Ogishi M, Rosain J, Martin E, Latour S, Vladikine N, Distefano M, Khan T, Rapaport F, Schulz MS, Holzer U, Fasth A, Sogkas G, Speckmann C, Troilo A, Bigley V, Roppelt A, Dinur-Schejter Y, Toker O, Bronken Martinsen KH, Sherkat R, Somekh I, Somech R, Shouval DS, Kühl JS, Ip W, McDermott EM, Cliffe L, Ozen A, Baris S, Rangarajan HG, Jouanguy E, Puel A, Bustamante J, Alyanakian MA, Fusaro M, Wang Y, Kong XF, Cobat A, Boutboul D, Castelle M, Aguilar C, Hermine O, Cheminant M, Suarez F, Yildiran A, Bousfiha A, Al-Mousa H, Alsohime F, Cagdas D, Abraham RS, Knutsen AP, Fevang B, Bhattad S, Kiykim A, Erman B, Arikoglu T, Unal E, Kumar A, Geier CB, Baumann U, Neven B; CARMIL2 Consortium; Rohlfs M, Walz C, Abel L, Malissen B, Marr N, Klein C, Casanova JL, Hauck F*, Béziat V*. Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency. J Exp Med. 2023 Feb 6;220(2), Epub 2022 Dec 14. doi: 10.1084/jem.20220275. (IF 17.579, Original Article). *These authors contributed equally.

Magg T, Okano T, Koenig LM, Boehmer DFR, Schwartz SL, Inoue K, Heimall J, Licciardi F, Ley-Zaporozhan J, Ferdman RM, Caballero-Oteyza A, Park EN, Calderon BM, Dey D, Kanegane H, Cho K, Montin D, Reiter K, Griese M, Albert MH, Rohlfs M, Gray P, Walz C, Conn GL, Sullivan KE, Klein C, Morio T, Hauck F. Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency. Sci Immunol. 2021 Jun 18;6(60): eabf9564. doi: 10.1126/sciimmunol.abf9564. (IF 30.63, Original Article).

Schober T, Magg T, Laschinger M, Rohlfs M, Linhares N.D., Puchalka1 J, Weisser T, Fehlner K, Mautner J, Walz C, Hussein K, Jaeger G, Kammer B, Schmid I, Bahia M, Pena S.D., Behrends U, Belohradsky B.H., Klein C*, Hauck F*. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017 Jan 23;8:14209. doi: 10.1038/ncomms14209. (IF 17.694, Original Article). *These authors contributed equally.

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Fabian Hauck Lab

Immunological Diagnostics Laboratoy, Room D1.20

Dr. von Hauner Children’s Hospital

Klinikum der Universität München

Lindwurmstr. 4, 80337 München, Germany

Tel.: +49 89 4400-52831

✉ Fabian.Hauck@med.uni-muenchen.de

☎ +49-89-4400-53931