Unsere Webseite nutzt Cookies, damit die User-Experience gesteigert wird. Bitte beachten Sie, dass ohne Cookies einige Funktionalitäten nicht mehr ausführbar sind (z. B. Formulare). Ausführlichere Hinweise zu Cookies
OK
en
  • German - de
  • English - en
  • Mission
  • Research Labs
      Binder Lab
        Braun Lab
          Feuchtinger Lab
            Griese Lab
              Hauck Lab
                Hübner Lab
                  Jeremias lab
                    Kim-Hellmuth Lab
                      Klein Lab
                        Kotlarz Lab
                          Lange-Sperandio Lab
                            von Mutius Lab
                              Schaub Lab
                                Schwerd Lab
                                  Schmid Lab
                                • Clinical research
                                    Interdisciplinary pediatric study center (Hauner iPSC)
                                      Ped-COVID-19 Study
                                        Michael Albert
                                          Scivias Study
                                            TRACE Study
                                          • PhD Program
                                          • Technology platforms
                                              Bioinformatics
                                                Flow Cytometry
                                                  High throughput sequencing
                                                    Microscopy
                                                      Pre-GMP Facility
                                                        Mass spectrometry
                                                          Hauner Biobank
                                                        • Events
                                                            Meinhard von Pfaundler-Lectures
                                                              Klaus Betke Symposium
                                                            • Join us!
                                                            • Contact
                                                            1. CCRC-HaunerEN
                                                            2. Research Labs
                                                            3. Lange-Sperandio Lab

                                                            Lange-Sperandio Lab

                                                            • Group Leader
                                                            • Research
                                                            • Group Members
                                                            • Publications
                                                            • Contact
                                                            Authorship unknown

                                                            Research topics

                                                            • Congenital anomalies of kidneys and urinary tract (CAKUT)
                                                            • Inflammation and fibrosis

                                                            • Kidney development

                                                            Prof. Dr. med. Bärbel Lange-Sperandio

                                                            ✉ baerbel.lange-sperandio@med.uni-muenchen.de

                                                            ☎ +49-89-4400-52811

                                                            Congenital anomalies of kidney and urinary tract (CAKUT) are the leading cause of end stage renal disease (ESRD) in children. CAKUT represents a wide spectrum of isolated unilateral or bilateral malformations. We are interested in discovering the causes of chronic renal failure following congenital obstruction of the urinary tract. We study obstructive uropathies in vitro and in vivo using newborn rodents. Our research group aims to identify molecular mechanisms, specific signaling pathways and mediators of inflammation and fibrosis in the developing kidney with obstruction. Our goal is to improve diagnostic and therapeutic strategies in children with CAKUT.

                                                            Authorship unknown

                                                            Prof. Dr. Bärbel Lange-Sperandio

                                                            Dr. Katharina Hermes

                                                            Maja Wyczanska (M.Sc.)

                                                            Ursula Keller

                                                            Selected Publications

                                                            Gasparitsch M, Schieber A, Schaubeck T, Keller U, Cattaruzza M, Lange-Sperandio B. Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. PloS One (2019), 14(12), e0226675.

                                                            Popper B, Rammer M T, Gasparitsch M, Singer T, Keller U, Döring Y, Lange-Sperandio B. Neonatal obstructive nephropathy induces necroptosis and necroinflammation. Scientific Reports (2019), 9(1), 1–11

                                                            Lange-Sperandio, B., Pediatric Obstructive Uropathy, in Pediatric Nephrology, D.E. Avner, Harmon, E.W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein L.S., Editor. 2016, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 1749-1777.

                                                            Gasparitsch M, Arndt AK, Pawlitschek F, Oberle S, Keller U, Kasper M, Bierhaus A, Schaefer F, Weber LT, Lange-Sperandio B. RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation. Kidney Int. 2013 Nov;84(5):911-9.

                                                            RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner. Frommhold D, Kamphues A, Dannenberg S, Buschmann K, Zablotskaya V, Tschada R, Lange-Sperandio B, Nawroth PP, Poeschl J, Bierhaus A, Sperandio M. BMC Immunol. 2011 Oct 4;12:56.

                                                            Lange-Sperandio B, Trautmann A, Eickelberg O, Jayachandran A, Oberle S, Schmidutz F, Rodenbeck B, Hömme M, Horuk R, Schaefer F. Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol. 2007 Sep;171(3):861-71.

                                                            Lange-Sperandio B, Schimpgen K, Rodenbeck B, Chavakis T, Bierhaus A, Nawroth P, Thornhill B, Schaefer F, Chevalier RL. Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy. Kidney Int. 2006 Jan;69(1):81-8.

                                                            Prof. Dr. med. Bärbel Lange-Sperandio


                                                            ✉ baerbel.lange-sperandio@med.uni-muenchen.de


                                                            Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital,

                                                            Klinikum der Universität München, LMU München


                                                            Postal Address: Lindwurmstr. 4

                                                            Visiting Address: Research Building, Lindwurmstraße 2a

                                                            80337 Munich

                                                            Germany


                                                            ☎ +49-89-4400-52811

                                                            Research at CCRC Hauner

                                                            Kontakt LMU Klinikum

                                                            Kontakt CCRC Hauner

                                                            CCRC Hauner

                                                            Kinderklinik und Kinderpoliklinik

                                                            im Dr. von Haunerschen Kinderspital

                                                            Ludwig Maximilians Universität München

                                                            Lindwurmstr. 4

                                                            80337 Munich, Germany

                                                            ☎ +49-89-4400-57705


                                                            Redakteurs Log-In
                                                            Imprint | Data-Safety
                                                            en
                                                            • German - de
                                                            • English - en

                                                            Comprehensiv...

                                                            • Mission
                                                            • Research Labs
                                                              • Binder Lab
                                                              • Braun Lab
                                                              • Feuchtinger Lab
                                                              • Griese Lab
                                                              • Hauck Lab
                                                              • Hübner Lab
                                                              • Jeremias lab
                                                              • Kim-Hellmuth Lab
                                                              • Klein Lab
                                                              • Kotlarz Lab
                                                              • Lange-Sperandio Lab
                                                              • von Mutius Lab
                                                              • Schaub Lab
                                                              • Schwerd Lab
                                                              • Schmid Lab
                                                            • Clinical research
                                                              • Interdisciplinary pediatric study center (Hauner iPSC)
                                                              • Ped-COVID-19 Study
                                                              • Michael Albert
                                                              • Scivias Study
                                                              • TRACE Study
                                                            • PhD Program
                                                            • Technology platforms
                                                              • Bioinformatics
                                                              • Flow Cytometry
                                                              • High throughput sequencing
                                                              • Microscopy
                                                              • Pre-GMP Facility
                                                              • Mass spectrometry
                                                              • Hauner Biobank
                                                            • Events
                                                              • Meinhard von Pfaundler-Lectures
                                                              • Klaus Betke Symposium
                                                            • Join us!
                                                            • Contact