Lange-Sperandio Lab

Congenital anomalies of kidney and urinary tract (CAKUT) are the leading cause of end stage renal disease (ESRD) in children. CAKUT represents a wide spectrum of isolated unilateral or bilateral malformations. We are interested in discovering the causes of chronic renal failure following congenital obstruction of the urinary tract. We study obstructive uropathies in vitro and in vivo using newborn rodents. Our research group aims to identify molecular mechanisms, specific signaling pathways and mediators of inflammation and fibrosis in the developing kidney with obstruction. Our goal is to improve diagnostic and therapeutic strategies in children with CAKUT.

Selected Publications

Gasparitsch M, Schieber A, Schaubeck T, Keller U, Cattaruzza M, Lange-Sperandio B. Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. PloS One (2019), 14(12), e0226675.

Popper B, Rammer M T, Gasparitsch M, Singer T, Keller U, Döring Y, Lange-Sperandio B. Neonatal obstructive nephropathy induces necroptosis and necroinflammation. Scientific Reports (2019), 9(1), 1–11

Lange-Sperandio, B., Pediatric Obstructive Uropathy, in Pediatric Nephrology, D.E. Avner, Harmon, E.W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein L.S., Editor. 2016, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 1749-1777.

Gasparitsch M, Arndt AK, Pawlitschek F, Oberle S, Keller U, Kasper M, Bierhaus A, Schaefer F, Weber LT, Lange-Sperandio B. RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation. Kidney Int. 2013 Nov;84(5):911-9.

RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner. Frommhold D, Kamphues A, Dannenberg S, Buschmann K, Zablotskaya V, Tschada R, Lange-Sperandio B, Nawroth PP, Poeschl J, Bierhaus A, Sperandio M. BMC Immunol. 2011 Oct 4;12:56.

Lange-Sperandio B, Trautmann A, Eickelberg O, Jayachandran A, Oberle S, Schmidutz F, Rodenbeck B, Hömme M, Horuk R, Schaefer F. Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol. 2007 Sep;171(3):861-71.

Lange-Sperandio B, Schimpgen K, Rodenbeck B, Chavakis T, Bierhaus A, Nawroth P, Thornhill B, Schaefer F, Chevalier RL. Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy. Kidney Int. 2006 Jan;69(1):81-8.

Lange-Sperandio Lab

Prof. Dr. med. Bärbel Lange-Sperandio

Selected Publications

Prof. Dr. med. Bärbel Lange-Sperandio

CCRC Hauner