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                                                          1. CCRC-HaunerEN
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                                                          3. Lange-Sperandio Lab

                                                          Lange-Sperandio Lab

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                                                          Urheberschaft ungeklärt

                                                          Research topics

                                                          • Congenital anomalies of kidneys and urinary tract (CAKUT)
                                                          • Inflammation and fibrosis

                                                          • Kidney development

                                                          Prof. Dr. med. Bärbel Lange-Sperandio

                                                          ✉ baerbel.lange-sperandio@med.uni-muenchen.de

                                                          ☎ +49-89-4400-52811

                                                          Congenital anomalies of kidney and urinary tract (CAKUT) are the leading cause of end stage renal disease (ESRD) in children. CAKUT represents a wide spectrum of isolated unilateral or bilateral malformations. We are interested in discovering the causes of chronic renal failure following congenital obstruction of the urinary tract. We study obstructive uropathies in vitro and in vivo using newborn rodents. Our research group aims to identify molecular mechanisms, specific signaling pathways and mediators of inflammation and fibrosis in the developing kidney with obstruction. Our goal is to improve diagnostic and therapeutic strategies in children with CAKUT.

                                                          Urheberschaft ungeklärt

                                                          Prof. Dr. Bärbel Lange-Sperandio

                                                          Dr. Katharina Hermes

                                                          Maja Wyczanska (M.Sc.)

                                                          Ursula Keller

                                                          Selected Publications

                                                          Gasparitsch M, Schieber A, Schaubeck T, Keller U, Cattaruzza M, Lange-Sperandio B. Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. PloS One (2019), 14(12), e0226675.

                                                          Popper B, Rammer M T, Gasparitsch M, Singer T, Keller U, Döring Y, Lange-Sperandio B. Neonatal obstructive nephropathy induces necroptosis and necroinflammation. Scientific Reports (2019), 9(1), 1–11

                                                          Lange-Sperandio, B., Pediatric Obstructive Uropathy, in Pediatric Nephrology, D.E. Avner, Harmon, E.W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein L.S., Editor. 2016, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 1749-1777.

                                                          Gasparitsch M, Arndt AK, Pawlitschek F, Oberle S, Keller U, Kasper M, Bierhaus A, Schaefer F, Weber LT, Lange-Sperandio B. RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation. Kidney Int. 2013 Nov;84(5):911-9.

                                                          RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner. Frommhold D, Kamphues A, Dannenberg S, Buschmann K, Zablotskaya V, Tschada R, Lange-Sperandio B, Nawroth PP, Poeschl J, Bierhaus A, Sperandio M. BMC Immunol. 2011 Oct 4;12:56.

                                                          Lange-Sperandio B, Trautmann A, Eickelberg O, Jayachandran A, Oberle S, Schmidutz F, Rodenbeck B, Hömme M, Horuk R, Schaefer F. Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol. 2007 Sep;171(3):861-71.

                                                          Lange-Sperandio B, Schimpgen K, Rodenbeck B, Chavakis T, Bierhaus A, Nawroth P, Thornhill B, Schaefer F, Chevalier RL. Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy. Kidney Int. 2006 Jan;69(1):81-8.

                                                          Prof. Dr. med. Bärbel Lange-Sperandio


                                                          ✉ baerbel.lange-sperandio@med.uni-muenchen.de


                                                          Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital,

                                                          Klinikum der Universität München, LMU München


                                                          Postal Address: Lindwurmstr. 4

                                                          Visiting Address: Research Building, Lindwurmstraße 2a

                                                          80337 Munich

                                                          Germany


                                                          ☎ +49-89-4400-52811

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                                                          CCRC Hauner

                                                          Kinderklinik und Kinderpoliklinik

                                                          im Dr. von Haunerschen Kinderspital

                                                          Ludwig Maximilians Universität München

                                                          Lindwurmstr. 4

                                                          80337 Munich, Germany

                                                          ☎ +49-89-4400-57705



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                                                          • Mission
                                                          • Research Labs
                                                            • Binder Lab
                                                            • Braun Lab
                                                            • Feuchtinger Lab
                                                            • Griese Lab
                                                            • Hauck Lab
                                                            • Hübner Lab
                                                            • Jeremias lab
                                                            • Kim-Hellmuth Lab
                                                            • Klein Lab
                                                            • Kotlarz Lab
                                                            • Lange-Sperandio Lab
                                                            • von Mutius Lab
                                                            • Schaub Lab
                                                            • Schwerd Lab
                                                            • Schmid Lab
                                                          • Clinical research
                                                            • Interdisciplinary pediatric study center
                                                            • Ped-COVID-19 Study
                                                            • Michael Albert
                                                            • Scivias Study
                                                          • PhD Program
                                                          • Technology platforms
                                                            • Bioinformatics
                                                            • Flow Cytometry
                                                            • High throughput sequencing
                                                            • Microscopy
                                                            • Pre-GMP Facility
                                                            • Mass spectrometry
                                                            • Hauner Biobank
                                                          • Events
                                                            • Meinhard von Pfaundler-Lectures
                                                            • Klaus Betke Symposium
                                                          • Join us!
                                                          • Contact