Organoid Lab
The Klein Lab established a dedicated well-equipped lab space to work on human induced pluripotent stem cell (iPSC)-derived organoids, currently focussing on a novel method for iPSC-derived bone marrow organoids.
Contact
Stephanie Frenz-Wiessner, MD
Klein Lab - Organoid Lab Head
✉ stephanie.frenz@med.uni-muenchen.de
Room: KU.10
Martina Kalauz
Klein Lab - Technician
✉ martina.kalauz@med.uni-muenchen.de
Room: KU.10
News
Bone marrow in miniature
Organoids - three-dimensional miniature models of organs - are less than a millimetre in size. Ideally, they should be able to replicate the functions of their larger counterparts. An interdisciplinary team of scientists at the Dr. von Haunerschen Children's Hospital of the LMU has now succeeded in constructing human bone marrow organoids. "We believe that this technology could prove useful in many ways - from modelling congenital and acquired bone marrow diseases to the biotechnological production of blood cells," says Professor Christoph Klein, Director of the LMU Children's Hospital and Children's Polyclinic. In the journal Nature Methods, the team has described in detail their innovative method for generating these complex human bone marrow organoids from induced pluripotent stem cells.
More information:
Publication
Frenz-Wiessner et al., Generation of complex bone marrow organoids from human induced pluripotent stem cells, 2024, Nature Methods.