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                                                          3. Schwerd Lab

                                                          Schwerd Lab

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                                                          Research topics

                                                          • Diet and microbiome
                                                          • Mucosal immunology
                                                          • Inflammatory bowel disease

                                                          Dr. med. Tobias Schwerd

                                                          ✉ tschwerd@med.lmu.de

                                                          ☎ +49-89-4400-57776

                                                          The gastrointestinal (GI) tract harbors a complex community of microbes (e.g. bacteria, fungi, archaea, viruses) and various food antigens. Diet is one of the key environmental factors that shapes the gut microbiota. In healthy individuals no pathologic features occur, despite lamina propria infiltration with various immune cells and separation from luminal microorganisms and dietary antigens by only a single epithelial layer and mucus. Complex regulatory pathways must therefore maintain intestinal immune homeostasis in a healthy GI tract.

                                                          My group focus on childhood inflammatory and allergic diseases of the GI tract caused by a dysregulated interaction between diet, the microbiome and the mucosal immune system, like inflammatory bowel diseases or eosinophilic esophagitis. 

                                                          Impact of exclusive enteral nutrition on microbiome signatures and function in pediatric Crohn’s disease (SFB1371/P01)

                                                          Crohn’s disease (CD), a major subtype of inflammatory bowel disease (IBD), is characterized by cycles of remission and relapse. Genetic susceptibility in combination with compositional and functional changes in the intestinal microbiome are considered to play a key role in the etiology of IBD. Exclusive enteral nutrition (EEN) is highly effective for induction of remission in pediatric CD. EEN means exclusive feeding with a liquid formula for eight weeks. EEN is able to control disease activity, supports mucosal healing, improves malnutrition and growth, and has an excellent safety profile. However, due to the highly demanding adherence to exclusive formula feeding, EEN is not considered a long-term maintenance treatment. Given that clinical efficacy of EEN in pediatric CD is associated with shifts in the intestinal microbiota, we aim to understand the role of the microbiota in EEN. Our work includes analysis of the types of bacteria present (microbiome sequencing), what they are doing (fecal microbiome) as well as examination of the gut immune cell signaling.

                                                          Weblink: SFB1371

                                                          Urheberschaft ungeklärt


                                                          Annecarin Brückner (BSc, MPH)

                                                          Study manager

                                                          ✉ Annecarin.Brueckner@med.uni-muenchen.de

                                                          ☎ 089-4400-57931

                                                          Room: G1.10


                                                          Kolja Siebert (MSc)

                                                          Doctoral Researcher (PhD track)

                                                          ✉ Kolja.Siebert@med.uni-muenchen.de

                                                          ☎ 089-4400-57776

                                                          Room: K0.21


                                                          Lisa Tenius (BSc)

                                                          Research dietitian

                                                          ✉ Lisa.Tenius@med.uni-muenchen.de

                                                          ☎ 089-4400-57931

                                                          Room: G1.10


                                                          Thu Giang Le Thi (MSc, MPH)

                                                          Study manager

                                                          ✉ Thu_Giang.Le_Thi@med.uni-muenchen.de

                                                          ☎ 089-4400-57854

                                                          Room: G1.10


                                                          Hannes Hölz (MD)

                                                          Postdoc

                                                          ✉ Hannes.Hoelz@med.uni-muenchen.de

                                                          ☎ 089-4400-57776

                                                          Room: K0.21

                                                          Publications

                                                          Content will be available soon.

                                                          Content will be available soon.

                                                          Schwerd Lab  / Translationale Gastroenterologie in der Pädiatrie


                                                          Kinderklinik und Kinderpoliklinik

                                                          im Dr. von Haunerschen Kinderspital

                                                          Ludwig Maximilians Universität München

                                                          Lindwurmstr. 4

                                                          80337 Munich, Germany


                                                          Visiting Adress:

                                                          Research Building, Lindwurmstraße 2a

                                                          Rooms KO.21

                                                          80337 Munich

                                                          Germany


                                                          Phone: +49 (0)89 4400-57776

                                                          Fax: +49 (0)89 4400-57898


                                                          tschwerd@med.lmu.de

                                                          Impressum

                                                          Datenschutz

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                                                          CCRC Hauner

                                                          Kinderklinik und Kinderpoliklinik

                                                          im Dr. von Haunerschen Kinderspital

                                                          Ludwig Maximilians Universität München

                                                          Lindwurmstr. 4

                                                          80337 Munich, Germany

                                                          ☎ +49-89-4400-57705



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                                                          • Mission
                                                          • Research Labs
                                                            • Binder Lab
                                                            • Braun Lab
                                                            • Feuchtinger Lab
                                                            • Griese Lab
                                                            • Hauck Lab
                                                            • Hübner Lab
                                                            • Jeremias lab
                                                            • Kim-Hellmuth Lab
                                                            • Klein Lab
                                                            • Kotlarz Lab
                                                            • Lange-Sperandio Lab
                                                            • von Mutius Lab
                                                            • Schaub Lab
                                                            • Schwerd Lab
                                                            • Schmid Lab
                                                          • Clinical research
                                                            • Interdisciplinary pediatric study center
                                                            • Ped-COVID-19 Study
                                                            • Michael Albert
                                                            • Scivias Study
                                                          • PhD Program
                                                          • Technology platforms
                                                            • Bioinformatics
                                                            • Flow Cytometry
                                                            • High throughput sequencing
                                                            • Microscopy
                                                            • Pre-GMP Facility
                                                            • Mass spectrometry
                                                            • Hauner Biobank
                                                          • Events
                                                            • Meinhard von Pfaundler-Lectures
                                                            • Klaus Betke Symposium
                                                          • Join us!
                                                          • Contact