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                                                              1. CCRC-HaunerEN
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                                                              Hauck Lab

                                                              • Research topics

                                                                • Autoinflammation

                                                                • Immunodeficiency
                                                                • Autoimmunity
                                                                • Immunological malignancy predisposition

                                                                Prof. Dr. Dr. med. Fabian Hauck

                                                                ✉ Fabian.Hauck@med.uni-muenchen.de

                                                                ☎ +49-89-4400-53931

                                                              • Inborn errors of immunity constitute a heterogeneous group of monogenetic model disorders that manifest with autoinflammation, immunodeficiency, autoimmunity and immunological malignancy predisposition. We aim at illuminating their molecular genetics and the molecular, cellular and systems biological pathophysiologies. We thereby increase our knowledge in human immunity and develop innovative prophylactic and therapeutic strategies for patients suffering from these rare diseases.

                                                              • PD Dr.med. Dr.sci.nat. Fabian Hauck

                                                                Dr. rer. nat. Thomas Magg

                                                                Dr. med. Anna-Lisa-Lanz

                                                                Dr. med. Johannes Rädler

                                                                Msc Jitka Smetanová

                                                                Irmgard Eckerlein (MTA)

                                                                Mayumi Hofmann (MTA)

                                                              • Selected publications


                                                                Mishra H, Schlack-Leigers C, Lim E L, Thieck O, Magg T, Raedler J, Wolf C, Klein C, Ewers H, Lee-Kirsch M A, Meierhofer D, Hauck F*, Majer O*. Endosome dysfunction leads to gain-of-function TLR7 and human lupus. bioRxiv: April 3, 2023. (Preprint, no IF, Original Article). *These authors contributed equally.

                                                                Speckmann C, Nennstiel U, Hönig M, Albert MH, Ghosh S, Schuetz C, Brockow I, Hörster F, Niehues T, Ehl S, Wahn V, Borte S, Lehmberg K, Baumann U, Beier R, Krüger R, Bakhtiar S, Kuehl JS, Klemann C, Kontny U, Holzer U, Meinhardt A, Morbach H, Naumann-Bartsch N, Rothoeft T, Kreins AY, Davies EG, Schneider DT, Bernuth HV, Klingebiel T, Hoffmann GF, Schulz A, Hauck F. Prospective Newborn Screening for SCID in Germany: A First Analysis by the Pediatric Immunology Working Group (API). J Clin Immunol. 2023 Feb 27:1-14. doi: 10.1007/s10875-023-01450-6. (IF 8.542, Original Article).

                                                                Lévy R, Gothe F, Momenilandi M, Magg T, Materna M, Peters P, Raedler J, Philippot Q, Rack-Hoch AL, Langlais D, Bourgey M, Lanz AL, Ogishi M, Rosain J, Martin E, Latour S, Vladikine N, Distefano M, Khan T, Rapaport F, Schulz MS, Holzer U, Fasth A, Sogkas G, Speckmann C, Troilo A, Bigley V, Roppelt A, Dinur-Schejter Y, Toker O, Bronken Martinsen KH, Sherkat R, Somekh I, Somech R, Shouval DS, Kühl JS, Ip W, McDermott EM, Cliffe L, Ozen A, Baris S, Rangarajan HG, Jouanguy E, Puel A, Bustamante J, Alyanakian MA, Fusaro M, Wang Y, Kong XF, Cobat A, Boutboul D, Castelle M, Aguilar C, Hermine O, Cheminant M, Suarez F, Yildiran A, Bousfiha A, Al-Mousa H, Alsohime F, Cagdas D, Abraham RS, Knutsen AP, Fevang B, Bhattad S, Kiykim A, Erman B, Arikoglu T, Unal E, Kumar A, Geier CB, Baumann U, Neven B; CARMIL2 Consortium; Rohlfs M, Walz C, Abel L, Malissen B, Marr N, Klein C, Casanova JL, Hauck F*, Béziat V*. Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency. J Exp Med. 2023 Feb 6;220(2), Epub 2022 Dec 14. doi: 10.1084/jem.20220275. (IF 17.579, Original Article). *These authors contributed equally.

                                                                Magg T, Okano T, Koenig LM, Boehmer DFR, Schwartz SL, Inoue K, Heimall J, Licciardi F, Ley-Zaporozhan J, Ferdman RM, Caballero-Oteyza A, Park EN, Calderon BM, Dey D, Kanegane H, Cho K, Montin D, Reiter K, Griese M, Albert MH, Rohlfs M, Gray P, Walz C, Conn GL, Sullivan KE, Klein C, Morio T, Hauck F. Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency. Sci Immunol. 2021 Jun 18;6(60): eabf9564. doi: 10.1126/sciimmunol.abf9564. (IF 30.63, Original Article).

                                                                Schober T, Magg T, Laschinger M, Rohlfs M, Linhares N.D., Puchalka1 J, Weisser T, Fehlner K, Mautner J, Walz C, Hussein K, Jaeger G, Kammer B, Schmid I, Bahia M, Pena S.D., Behrends U, Belohradsky B.H., Klein C*, Hauck F*. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017 Jan 23;8:14209. doi: 10.1038/ncomms14209. (IF 17.694, Original Article). *These authors contributed equally.


                                                                Full list: click here.  

                                                              • Fabian Hauck Lab


                                                                Immunological Diagnostics Laboratoy, Room D1.20

                                                                Dr. von Hauner Children’s Hospital

                                                                Klinikum der Universität München

                                                                Lindwurmstr. 4, 80337 München, Germany

                                                                Tel.: +49 89 4400-52831


                                                                ✉ Fabian.Hauck@med.uni-muenchen.de

                                                                ☎ +49-89-4400-53931


                                                              Research at CCRC Hauner

                                                              Contact LMU Klinikum

                                                              Contact CCRC Hauner

                                                              Haunersches

                                                              CCRC Hauner

                                                              Kinderklinik und Kinderpoliklinik

                                                              im Dr. von Haunerschen Kinderspital

                                                              Ludwig Maximilians Universität München

                                                              Lindwurmstr. 4

                                                              80337 Munich, Germany

                                                              ☎ +49-89-4400-57705

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                                                              en
                                                              • German - de
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                                                              Comprehensiv...

                                                              • Clinical research
                                                                • Interdisciplinary pediatric study center (Hauner iPSC)
                                                                • Ped-COVID-19 Study
                                                                • Michael Albert
                                                                • Scivias Study
                                                                • TRACE Study
                                                              • Research Labs
                                                                • Binder Lab
                                                                • Braun Lab
                                                                • Feuchtinger Lab
                                                                • Griese Lab
                                                                • Hauck Lab
                                                                • Hübner Lab
                                                                • Jeremias lab
                                                                • Kim-Hellmuth Lab
                                                                • Klein Lab
                                                                • Kotlarz Lab
                                                                • Lange-Sperandio Lab
                                                                • von Mutius Lab
                                                                • Schaub Lab
                                                                • Schwerd Lab
                                                                • Schmid Lab
                                                                • Koletzko Lab
                                                              • PhD Program
                                                              • Technology platforms
                                                                • Bioinformatics
                                                                • Flow Cytometry
                                                                • High throughput sequencing
                                                                • Microscopy
                                                                • Pre-GMP Facility
                                                                • Mass spectrometry
                                                                • Hauner Biobank
                                                              • News/Events
                                                                • Meinhard von Pfaundler-Lectures
                                                                • Klaus Betke Symposium
                                                              • Join us!