At our comprehensive childhood research center, numerous clinical studies are under way. Children constitute an especially vulnerable group of patients. Therefore, clinical research must respect highest ethical standards. In view of increasing complexities with respect to regulatory frameworks, clinical research involving pediatric patients at the Dr. von Hauner Children's Hospital has been put under the auspices of the interdisciplinary pediatric study center (iPSC-Hauner). The iPSC-Hauner assists physicians in designing and preparing a clinical study, helps with budgetary issues, provides harmonized quality control and risk assessment strategies, establishes links to strategic partners such as the local Institutional Review Board as well as regional and national authorities. The iPSC Hauner is part of the newly established EU-funded platform for pediatric studies.