en
  • German - de
  • English - en
  • Research Labs
      Binder Lab
        Braun Lab
          Feuchtinger Lab
            Griese Lab
              Hauck Lab
                Hübner Lab
                  Jeremias lab
                    Kim-Hellmuth Lab
                      Klein Lab
                        Kotlarz Lab
                          Lange-Sperandio Lab
                            von Mutius Lab
                              Schaub Lab
                                Schwerd Lab
                                  Schmid Lab
                                • Clinical research
                                    Interdisciplinary pediatric study center (Hauner iPSC)
                                      Ped-COVID-19 Study
                                        Michael Albert
                                          Scivias Study
                                            TRACE Study
                                          • PhD Program
                                          • Technology platforms
                                              Bioinformatics
                                                Flow Cytometry
                                                  High throughput sequencing
                                                    Microscopy
                                                      Pre-GMP Facility
                                                        Mass spectrometry
                                                          Hauner Biobank
                                                        • News/Events
                                                            Meinhard von Pfaundler-Lectures
                                                              Klaus Betke Symposium
                                                            • Join us!
                                                            1. CCRC-HaunerEN
                                                            2. Research Labs
                                                            3. Schwerd Lab

                                                            Schwerd Lab

                                                            • Group Leader
                                                            • Research
                                                            • Group Members
                                                            • Publications
                                                            • Funding
                                                            • Impressions
                                                            • NEWS
                                                            • Contact

                                                            Research topics

                                                            • Diet and microbiome
                                                            • Mucosal immunology
                                                            • Inflammatory bowel disease
                                                            • Eosinophilic esophagitis

                                                            PD Dr. med. Tobias Schwerd

                                                            ✉ tschwerd@med.lmu.de

                                                            ☎ +49-89-4400-57776

                                                            The gastrointestinal (GI) tract harbors a complex community of microbes (e.g. bacteria, fungi, archaea, viruses) and various food antigens. Diet is one of the key environmental factors that shapes the gut microbiota. In healthy individuals no pathologic features occur, despite lamina propria infiltration with various immune cells and separation from luminal microorganisms and dietary antigens by only a single epithelial layer and mucus. Complex regulatory pathways must therefore maintain intestinal immune homeostasis in a healthy GI tract.

                                                            My group focus on childhood inflammatory and allergic diseases of the GI tract caused by a dysregulated interaction between diet, the microbiome and the mucosal immune system, like inflammatory bowel diseases or eosinophilic esophagitis. 

                                                            Impact of exclusive enteral nutrition on microbiome signatures and function in pediatric Crohn’s disease (SFB1371/P01)

                                                            Crohn’s disease (CD), a major subtype of inflammatory bowel disease (IBD), is characterized by cycles of remission and relapse. Genetic susceptibility in combination with compositional and functional changes in the intestinal microbiome are considered to play a key role in the etiology of IBD. Exclusive enteral nutrition (EEN) is highly effective for induction of remission in pediatric CD. EEN means exclusive feeding with a liquid formula for eight weeks. EEN is able to control disease activity, supports mucosal healing, improves malnutrition and growth, and has an excellent safety profile. However, due to the highly demanding adherence to exclusive formula feeding, EEN is not considered a long-term maintenance treatment. Given that clinical efficacy of EEN in pediatric CD is associated with shifts in the intestinal microbiota, we aim to understand the role of the microbiota in EEN. Our work includes analysis of the types of bacteria present (microbiome sequencing), what they are doing (fecal microbiome) as well as examination of the gut immune cell signaling.

                                                            Weblink: SFB1371

                                                            Crohn’s disease (CD), a major subtype of inflammatory bowel disease (IBD), is characterized by cycles of remission and relapse. Genetic susceptibility in combination with compositional and functional changes in the intestinal microbiome are considered to play a key role in the etiology of IBD. Exclusive enteral nutrition (EEN) is highly effective for induction of remission in pediatric CD. EEN means exclusive feeding with a liquid formula for eight weeks. EEN is able to control disease activity, supports mucosal healing, improves malnutrition and growth, and has an excellent safety profile. However, due to the highly demanding adherence to exclusive formula feeding, EEN is not considered a long-term maintenance treatment. Given that clinical efficacy of EEN in pediatric CD is associated with shifts in the intestinal microbiota, we aim to understand the role of the microbiota in EEN. Our work includes analysis of the types of bacteria present (microbiome sequencing), what they are doing (fecal microbiome) as well as examination of the gut immune cell signaling.

                                                            Weblink: SFB1371

                                                            Logo project CRC 1371
                                                            T-cell immunity in childhood and adolescent eosinophilic esophagitis. Longitudinal study of the interaction between the immune system, microbiome and nutrition (EoE-LIME)
                                                            Abbildung 1: Multiplex-Immunfluoreszenzfärbung einer Ösophagusbiopsie. Von einem Patienten mit aktiver Eosinophiler Ösophagitis ist eine Ösophagusbiopsie in der Übersicht gezeigt (Maßstab siehe links unten im Bild). Neben der Kernfärbung (DAPI) wurden eosinophile Granulozyten (EPX+), Mastzellen (MCT+) und T-Zellsubpopulationen (CD3+, CD4+, CD8+, FoxP3+) angefärbt.
                                                            LMU Klinikum - AG Schwerd - EoE Forschungsgruppe
                                                            Abbildung 1: Multiplex-Immunfluoreszenzfärbung einer Ösophagusbiopsie. Von einem Patienten mit aktiver Eosinophiler Ösophagitis ist eine Ösophagusbiopsie in der Übersicht gezeigt (Maßstab siehe links unten im Bild). Neben der Kernfärbung (DAPI) wurden eosinophile Granulozyten (EPX+), Mastzellen (MCT+) und T-Zellsubpopulationen (CD3+, CD4+, CD8+, FoxP3+) angefärbt.

                                                            Eosinophilic esophagitis (EoE) is a chronic, immune- and antigen-mediated disease of the esophagus that leads to esophageal dysfunction. The etiology is multifactorial and still poorly understood. Besides genetic factors, environmental allergens in food or air play a crucial role. IgE-mediated hypersensitivity and a delayed T-cell-mediated immune response using Th2 interleukins (IL) IL-4, IL-5, and IL-13 result in the recruitment and activation of eosinophils, basophils, and mast cells. The aim of the study is to describe and functionally characterize T cell subpopulations with respect to their influence on eosinophilic inflammation and inflammatory resolution in the context of environmental factors (food allergens, microbiome) in EoE.”

                                                            Lab Team

                                                            LMU Klinikum - Schwerd Lab

                                                            Research Group Leader

                                                            PD Dr. Tobias Schwerd

                                                            Tobias Schwerd (MD)

                                                            Research group leader

                                                            ✉ Tobias.Schwerd@med.uni-muenchen.de

                                                            ☎ 089-4400-57776

                                                            Room: K0.21


                                                            Hannes Hölz (MD)

                                                            Postdoc

                                                            ✉ Hannes.Hoelz@med.uni-muenchen.de

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Jeannine Heetmeyer (MD)

                                                            Medical researcher

                                                            ✉ jeannine.heetmeyer@med.uni-muenchen.de

                                                            ☎ 089-4400-57855

                                                            Room: G1.13

                                                            Kolja Siebert (MSc)

                                                            Doctoral researcher (PhD track)

                                                            ✉ Kolja.Siebert@med.uni-muenchen.de

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Simon Bühler

                                                            Doctoral researcher (MD track)

                                                            ✉ Simon.Buehler@med.uni-muenchen.de 

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Lena Bragagna

                                                            Doctoral researcher (MD track)

                                                            ✉ Lena.Bragagna@med.uni-muenchen.de 

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Maximilian Koch

                                                            Doctoral researcher (MD track)

                                                            ✉ Maximilian.Koch@med.uni-muenchen.de 

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Tim Faro

                                                            Research Assistant

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Marie-Luise Frank

                                                            Doctoral researcher (MD track)

                                                            ✉ Marie-Luise.Frank@med.uni-muenchen.de

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Anja Jurk

                                                            Doctoral researcher (MD track)

                                                            ✉ Anja.Jurk@med.uni-muenchen.de

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Platzhalter Foto

                                                            Katharina Socas

                                                            Doctoral researcher (MD track)

                                                            ✉ Katarina.Socas@med.uni-muenchen.de

                                                            ☎ 089-4400-57776

                                                            Room: K0.21

                                                            Clinical Study Team

                                                            LMU Klinikum - AG Schwerd plus Studienteam

                                                            Dr. Federica De Zen

                                                            Study manager

                                                            ✉ Federica.De-Zen@med.uni-muenchen.de

                                                            ☎ 089-4400-57931

                                                            Room: G1.10

                                                            Thu Giang Le Thi (MSc, MPH)

                                                            Study manager (PhD track)

                                                            ✉ Thu_Giang.Le_Thi@med.uni-muenchen.de

                                                            ☎ 089-4400-57854

                                                            Room: G1.10

                                                            Katarina Csollarova (Dipl. oec. troph. univ., MPH)

                                                            Study manager

                                                            ✉ katarina.csollarova@med.uni-muenchen.de

                                                            ☎ 089-4400-57958

                                                            Room: G1.13


                                                            Alexandra Fabry-Said (MA. rer. nat)

                                                            Study manager

                                                            ✉ Alexandra.Said@med.uni-muenchen.de

                                                            ☎ 089-4400-57954

                                                            Room: G1.10

                                                            Dr. Katharina Werkstetter (MSC, MPH)

                                                            Study manager

                                                            ✉ katharina.werkstetter@med.uni-muenchen.de

                                                            ☎ 089-4400-53680

                                                            Room: G1.13

                                                            Verena Wegmann

                                                            Dietitian

                                                            ✉ Verena.Wegmann@med.uni-muenchen.de

                                                            ☎ 089-4400-57958

                                                            Room: G1.10

                                                            Alumni


                                                            Lisa Tenius, BSc

                                                            Dietitian



                                                            Milena Geist

                                                            Intern (BSc track)


                                                            Dr. Annecarin Brückner, MPH

                                                            Study manager



                                                            Bernadett Boeing, MSc

                                                            Study manager


                                                            Moritz Brammer

                                                            Research Assistant


                                                            • Koletzko L, Klucker E, Le Thi TG, Breiteneicher S, Rubio-Acero R, Neuhaus L, Stark RG, Standl M, Wieser A, Töröl H, Koletzko S, Schwerd T. Following Pediatric and Adult IBD Patients through the COVID-19 Pandemic: Changes in Psychosocial Burden and Perception of Infection Risk and Harm over Time. J Clin Med. 2021, 10(18), 4124;
                                                            • Bruckner A, Werkstetter KJ, Frivolt K, Shokry E, Ahmed M, Metwaly A, Marques JG, Uhl O, Krohn K, Hajji M, Otte S, Pozza SB, Bufler P, Liptay S, Haller D, Koletzko B, Koletzko S, Schwerd T. Partial enteral nutrition has no benefit on bone health but improves growth in paediatric patients with quiescent or mild Crohn's disease. Clin Nutr. 2020 Dec;39(12):3786-3796.

                                                            • Serra EG, Schwerd T, Moutsianas L, Cavounidis A, Fachal L, Pandey S, Kammermeier J, Croft NM, Posovszky C, Rodrigues A, Russell RK, Barakat F, Auth MKH, Heuschkel R, Zilbauer M, Fyderek K, Braegger C, Travis SP, Satsangi J, Parkes M, Thapar N, Ferry H, Matte JC, Gilmour KC, Wedrychowicz A, Sullivan P, Moore C, Sambrook J, Ouwehand W, Roberts D, Danesh J, Baeumler TA, Fulga TA, Karaminejadranjbar M, Ahmed A, Wilson R, Barrett JC, Elkadri A, Griffiths AM, investigators CiIg, Oxford IBDcsi, Study I, Swiss IBDci, Consortium UIG, Consortium NIG, Snapper SB, Shah N, Muise AM, Wilson DC, Uhlig HH, Anderson CA. Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease. Nat Commun 2020;11:995.

                                                            • Schwerd T, Bryant RV, Pandey S, Capitani M, Meran L, Cazier JB, Jung J, Mondal K, Parkes M, Mathew CG, Fiedler K, McCarthy DJ, Consortium WGS, Oxford IBDcsi, investigators CiIg, Consortium UIG, Sullivan PB, Rodrigues A, Travis SPL, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J, Study I, Russell RK, Wilson DC, Kelsen JR, Cornall R, Denson LA, Kugathasan S, Knaus UG, Serra EG, Anderson CA, Duerr RH, McGovern DP, Cho J, Powrie F, Li VS, Muise AM, Uhlig HH. NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease. Mucosal Immunol 2018;11:562-574.

                                                            • Schwerd T, Twigg SRF, Aschenbrenner D, Manrique S, Miller KA, Taylor IB, Capitani M, McGowan SJ, Sweeney E, Weber A, Chen L, Bowness P, Riordan A, Cant A, Freeman AF, Milner JD, Holland SM, Frede N, Muller M, Schmidt-Arras D, Grimbacher B, Wall SA, Jones EY, Wilkie AOM, Uhlig HH. A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med 2017;214:2547-2562.

                                                            • Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Duker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH. Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease. Gut 2017;66:1060-1073.

                                                            • Schwerd T, Frivolt K, Clavel T, Lagkouvardos I, Katona G, Mayr D, Uhlig HH, Haller D, Koletzko S, Bufler P. Exclusive enteral nutrition in active pediatric Crohn disease: Effects on intestinal microbiota and immune regulation. J Allergy Clin Immunol 2016;138:592-6.

                                                            • Schwerd T, Khaled AV, Schurmann M, Chen H, Handel N, Reis A, Gillessen-Kaesbach G, Uhlig HH, Abou Jamra R. A recessive form of extreme macrocephaly and mild intellectual disability complements the spectrum of PTEN hamartoma tumour syndrome. Eur J Hum Genet 2016;24:889-94.

                                                            • Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM, Group CiIS, Neopics. The diagnostic approach to monogenic very early onset inflammatory bowel disease. Gastroenterology 2014;147:990-1007 e3.

                                                            • Frivolt K, Schwerd T, Werkstetter KJ, Schwarzer A, Schatz SB, Bufler P, Koletzko S. Repeated exclusive enteral nutrition in the treatment of paediatric Crohn's disease: predictors of efficacy and outcome. Aliment Pharmacol Ther 2014;39:1398-407.

                                                            complete publications of Dr. Tobias Schwerd




                                                            AG Schwerd 2019

                                                            LMU Klinikum - AG Schwerd 2019

                                                            April 2022: Marie-Luise Frank presented her thesis work

                                                            Successful presentation of her thesis work at the annual FöFoLe seminar in Herrsching April 2022: well done Marie-Luise!

                                                            April 2022: New colleagues in our team!

                                                            Jeannine Heetmeyer (MD) - Lab and Clinical Study Team 

                                                            Katarina Csollarova (Dipl. oek. troph. univ, MPH) - Clinical Study Team

                                                            Dr. Katharina Werkstetter (MSc, MPH) - Clinical Study Team

                                                            will support our upcoming study projects! 

                                                            Feb 2022: New medical doctoral candidates in our lab!

                                                            Platzhalter Foto

                                                            We welcome our new medical doctoral candidates

                                                            cand med. Anja Jurk

                                                            cand. med. Katharina Socas and

                                                            cand. med. Maximilian Koch

                                                            in our laboratory - welcome to our research team!

                                                            July 2021: Tobias Schwerd is awarded the ECCO Grant for the research project “Tissue-associated microbial and cellular drivers of resolution of inflammation and disease exacerbation in a long-term cohort of paediatric CD patients”

                                                            ECCO

                                                            ECCO Fellowships, Grants and Travel Awards are available to encourage young physicians in their career and to promote innovative scientific research in IBD in Europe.

                                                            October 2021: Hannes Hölz will present e-Poster at UEG Week conference

                                                            UEG

                                                            The step-up treatment approach in pediatric ulcerative colitis results in frequent relapses: a retrospective analysis according to STRIDE-II (Selecting Therapeutic Targets in Inflammatory Bowel Disease) recommendations

                                                            H. Hölz 1, M.-L. Frank 1, L. Bragagna 1, S. Bühler 1, K. Siebert 1, A. Brückner 1, F. De Zen 1, E. Klucker 1, 2, T. Foerg 1, K. Krohn 2, E. Lurz 1, M.S. Hajji 1, S. Koletzko 1,3, T.G. Le Thi 1 and T. Schwerd 1

                                                            1 Department of Pediatrics, Dr. von Hauner Children’s Hospital and 2 Department of Pediatric Gastroenterology & Hepatology, Integrated Social Pediatric Center (iSPZ Hauner), University Hospital, LMU Munich, Germany 3 Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.

                                                            April 2021: Simon Bühler won the best poster presentation of the Society for Pediatric Gastroenterology and Nutrition (GPGE)

                                                            AG Schwerd - GPGE 2021

                                                            Retrospektive Analyse der Erstlinientherapie und des Verlaufs bei pädiatrischen Patienten mit eosinophiler Ösophagitis vor und nach Aktualisierung der Therapieempfehlungen im Jahr 2017

                                                            S. Bühler, H. Hölz, E. Lurz, E. Klucker, T. Förg, S. Koletzko, M. S. Hajji, T. Schwerd

                                                            Abteilung für pädiatrische Gastroenterologie, Hepatologie und Ernährung, Dr. von Haunersches Kinderspital, Klinikum der Ludwig-Maximilians-Universität, München 

                                                            April 2021: Hannes Hölz held oral presentation at the 36th Annual Meeting of the Society for Pediatric Gastroenterology and Nutrition (GPGE)

                                                            AG Schwerd - GPGE 2021

                                                            Therapieziele bei pädiatrischer CED: Retrospektive Auswertung anhand der aktualisierten STRIDE-II-Kriterien

                                                            H. Hölz, A. Brückner, F. De Zen, K. Siebert, S. Bühler, J. Seyffarth, J. F. Grill, M. Kurzay, E. S. Klucker, T. Förg, G. T. Le Thi, S. Koletzko, K. Krohn, E. Lurz, M. S. Hajji, T. Schwerd

                                                            Abteilung für Pädiatrische Gastroenterologie und Hepatologie, Dr. von Haunersches Kinderspital, Klinikum der Ludwig-Maximilians-Universität, München  

                                                            Schwerd Lab  / Translationale Gastroenterologie in der Pädiatrie


                                                            Kinderklinik und Kinderpoliklinik

                                                            im Dr. von Haunerschen Kinderspital

                                                            Ludwig Maximilians Universität München

                                                            Lindwurmstr. 4

                                                            80337 Munich, Germany


                                                            Visiting Adress:

                                                            Research Building, Lindwurmstraße 2a

                                                            Rooms KO.21

                                                            80337 Munich

                                                            Germany


                                                            Phone: +49 (0)89 4400-57776

                                                            Fax: +49 (0)89 4400-57898


                                                            tschwerd@med.lmu.de

                                                            Research at CCRC Hauner

                                                            Contact LMU Klinikum

                                                            Contact CCRC Hauner

                                                            Haunersches

                                                            CCRC Hauner

                                                            Kinderklinik und Kinderpoliklinik

                                                            im Dr. von Haunerschen Kinderspital

                                                            Ludwig Maximilians Universität München

                                                            Lindwurmstr. 4

                                                            80337 Munich, Germany

                                                            ☎ +49-89-4400-57705

                                                            Redakteurs Log-In
                                                            Imprint | Data-Safety
                                                            en
                                                            • German - de
                                                            • English - en

                                                            Comprehensiv...

                                                            • Research Labs
                                                              • Binder Lab
                                                              • Braun Lab
                                                              • Feuchtinger Lab
                                                              • Griese Lab
                                                              • Hauck Lab
                                                              • Hübner Lab
                                                              • Jeremias lab
                                                              • Kim-Hellmuth Lab
                                                              • Klein Lab
                                                              • Kotlarz Lab
                                                              • Lange-Sperandio Lab
                                                              • von Mutius Lab
                                                              • Schaub Lab
                                                              • Schwerd Lab
                                                              • Schmid Lab
                                                            • Clinical research
                                                              • Interdisciplinary pediatric study center (Hauner iPSC)
                                                              • Ped-COVID-19 Study
                                                              • Michael Albert
                                                              • Scivias Study
                                                              • TRACE Study
                                                            • PhD Program
                                                            • Technology platforms
                                                              • Bioinformatics
                                                              • Flow Cytometry
                                                              • High throughput sequencing
                                                              • Microscopy
                                                              • Pre-GMP Facility
                                                              • Mass spectrometry
                                                              • Hauner Biobank
                                                            • News/Events
                                                              • Meinhard von Pfaundler-Lectures
                                                              • Klaus Betke Symposium
                                                            • Join us!